Key Metrics

Mechanism of Action & Benefits

• Produces a heat-labile 54kDa serine protease that cleaves Clostridioides difficile toxins A and B, reducing their binding to and damage of the colonic mucosa
• Secretes a 63kDa phosphatase that dephosphorylates and inactivates E. coli lipopolysaccharide (LPS); also secretes a non-enzymatic protein that reduces cholera-toxin-induced cAMP generation in intestinal epithelial cells
• Exerts trophic effects on the intestinal mucosa, increasing brush-border disaccharidase activity and supporting epithelial renewal and villus recovery after diarrheal injury
• Competes with and reduces adhesion and colonization by enteric pathogens, helping normalize gut microbiota after dysbiosis or antibiotic exposure
• Stimulates local and systemic immune responses, including secretory IgA production, while limiting excessive inflammatory signaling
• Extensively documented in the literature to reduce the incidence and duration of acute and antibiotic-associated diarrhea
• A heat-tolerant, non-colonizing transient yeast that survives gastrointestinal transit without permanently colonizing the gut, well suited to short-term dietary supplementation

Recommended Dosage

Recommended minimum inclusion: 0.1–2×10⁸ CFU per kg body weight, adjusted by target species. For feed inclusion, calculate from body weight and target intake.